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KMID : 0351819930340040339
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Kyunpook University Medical Journal
1993 Volume.34 No. 4 p.339 ~ p.348
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Effects of High Na+ in the Lateral Ventricle on Cardiovascular System
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Abstract
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This study was performed to examine the effects of high concentration of NaCl in the lateral ventricle on blood pressure and heart rate, and to investigate the effects of losartan and hemorrhage on the cardiovascular response.
Under perntobarbital anesthesia, stainless steel cannula (22 gauge) was implanted stereotaxically in the lateral ventricle of male Wistar rats according to Paxinos' brain atlas. After a 5-day recovery period. the femoral artery was catheterized
with
PE50 tubing with heaprinized saline. The surgical procedures were performed under thiopental anesthesia. After recovery mannitol, glucose or NaCl solution was infused into the lateral ventricle through the cannula at a rate of 2 l/min for 10 min.
Acute
hemorrhage (0.5ml/100gm) was performed before and infusion of 2900 mOsm/l NaCl solution.
infusion of 300 mOsm/l NaCl solution did not change the mean arterial pressure (MAP) and heart rate (HR). Hypertonic solution of mannitol (960mOsm/l) and glucose (2900mOsm/l) did not make any difference. After infusion of 960 and 2900 mOsm/l NaCl
solution, however, MAP was inverased greatly and HR was also decreased greatly and there was no significant difference between the two osmolality groups. Changes in MAP and HR were attenuated by losartan pretreatment. Pretreatment with 2900
mOsm/l
NaCl
solution resulted in less decrease in MAP caused by hemorrhage. These results suggest that high Na+ in the lateral ventricle prodeces an increase in MAP increased symphathetic nervous system activity but not by an osmotic effect. In this respect,
high
Na+ might be helpful in recovering from blood loss.
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KEYWORD
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